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Dr Varghese is a world renowned scientist having solved the structure of influenza neuraminidase with Dr Peter Colman at CSIRO in 1983‚ was involved in the development of RelenzaTM‚ the first structure based anti-viral drug designed. Since then he has worked on the structural basis of drug resistance to neuraminidase inhibitors and has carried out seminal studies on the design of drugs against rapidly mutating targets. He was involved determining the structures of several medically important protein structures and is currently working on Alzheimer\'s Disease and brain receptor structures in the CSIRO P-health Flagship.
Jose is also a key participant in the Australian Synchrotron Project‚ leading the design and construction of two Protein Crystallography beamlines and is a member in the ARC Centre of Excellence in Coherent X-ray Science. Jose will discuss Influenza drug resistance studies and where we stand on the verge of a potential new pandemic arising from the virulent Avian strains that are now emerging worldwide.
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